Table of Contents

1. The Tumor Stroma: Key Component of Solid Tumors

Jai Prakash

2. Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma

Ahmed M. R. H. Mostafa, Alaa M. Ramadan, Arne Östman, and Jai Prakash

3. Tumor-Associated Macrophages: Biological Understanding and Therapeutic Opportunities

Siavash Mansouri and Rajkumar Savai

4. Biomarkers in the Tumor Stroma and Their Clinical Relevance

Barnali Deb, Rajan Datar, Sewanti Limaye, and Prashant Kumar

5. Physical Properties of the Tumor Stroma and Therapeutic Strategies

Zalak Bhut, Marcel Alexander Heinrich, and Jai Prakash

6. TGF-β Signalling in Cancer: Role and Therapeutic Targeting of the Tumour Stroma

Adilson Fonseca Teixeira, Peter ten Dijke, and Hong-Jian Zhu

7. Role of Integrins in the Tumor Stroma

Kunal Pednekar, Marcel Alexander Heinrich, and Jai Prakash

8. MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications

Tao Lu, Leon W. M. M. Terstappen, and Jai Prakash

9. Molecular Imaging of the Tumor Stroma and Beyond

F. A. Vuijk, R. Houvast, V. M. Baart, C. J. H. van de Velde, A. L. Vahrmeijer, D. E. Hilling, J. S. D. Mieog, M. Slingerland, L. F. de Geus-Oei, L. J. A. C. Hawinkels, and C. F. M Sier

10. 3D in vitro Models to Mimic the Tumor Microenvironment

Marcel Alexander Heinrich, Ngoc Tien Huynh, Yu Shrike Zhang, and Jai Prakash